The Cacna2d1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CACNA2D1. This antibody recognizes Human, Mouse, and Rat antigen. The Cacna2d1 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Subunit Structure: Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
Post-translational Modifications: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.
Similarity: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. Belongs to the calcium channel subunit alpha-2/delta family